The villa is easily accessible by car, as it is located just off the main road that connects Athens with the nearby seaside towns of Nea Makri and Marathon. The journey from Athens city center takes approximately 45 minutes by car and 1 hour from the airport, depending on traffic conditions.

Airport to Villa Amfiario by car: From Athens International Airport take the
Attiki Odos
-Use the right 2 lanes to take exit 8 to merge onto A/D Pireos Athinon Thessalonikis Evzonon/E75 toward LAMIA
-Take the exit toward KAPANDRITI/KALAMOS
-Take Leof. Kalamou and EO Oiou Amfiariou
-Exit on your right at 81 lane and the Villa is located just after the Saint Sofia's church